Leuprorelin Acetate

Product Introduction

Leuprolide acetate is a commonly used hormone anti-cancer drug, it is an acetate of leuprolide which is a nonapeptide synthetic analogue of LHRH (one kind decapeptide), it is a LH-RH antagonist. LHRH is produced by the hypothalamus, it can promote pituitary for the release of gonadotropins and follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This product's structure is similar to LHRH, its acting on the anterior pituitary which prompts FSH, LH release function, increases serum concentrations of testosterone and dihydrotestosterone.

But in about one week after use of the product, the number of active receptors will be reduced, and gonadotropin secretion will be reduced. After 2 to 4 weeks, the concentration of testosterone and dihydrotestosterone can be reduced to castration levels. After the withdrawal, gonadotropin and androgen concentrations can be recovered to normal.

Application

Leuprolide acetate (Leupron) is used to treat Prostatic carcinoma. It has also been investigated for the treatment of advanced breast cancer.