Gonadorelin Acetate

Product Introduction

Gonadorelin is a synthetic decapeptide with a structure identical with the natural Gonadotrophin Releasing Hormone (Gn-RH) in mammalian species. Gonadorelin is recommended for the treatment of reproductive disorders associated with ovarian cysts and for improvement of fertility in cows and for the induction of ovulation in rabbits. The mechanism of action underlying the therapeutic use is the stimulation of the release from and also the synthesis of LH and FSH in the anterior pituitary gland.

Gonadorelin is an agonist of the GnRH receptor and is used to induce the secretion of the gonadotropins follicle-stimulating hormone and luteinizing hormone from the pituitary gland and to increase sex hormone production by the gonads.

Application

Synthetic GnRH (gonadorelin hydrochloride) is marketed for diagnostic purposes to differentiate between pituitary and hypothalamic defects. Synthetic GnRH (gonadorelin acetate) is marketed for the treatment of infertile women who are anovulatory and have GnRH deficiency. Also used in agricultural studies for ovulation synchronization in dairy cows.